Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Good
Based on 8 Reviews
8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%

Top Medical Research Studies

We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.

In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.

Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
Read More
9.5
Selenium nanoparticles combat bacterial infections
We explored how selenium nanoparticles (SeNPs) can tackle bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). By modifying the surface chemistry of SeNPs using different surfactants, we could influence their effectiveness in fighting bacteria and modulating immune responses.

Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.

In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Read More
We explored the potential of selenium nanoparticles (SeNPs) as a treatment option for Pseudomonas aeruginosa, a notorious bacteria known for its antibiotic resistance and ability to form biofilms. The study examined how effectively these SeNPs can target bacterial infections, particularly focusing on their antibacterial and anti-biofilm properties.

SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.

Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.

Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
Read More

Most Useful Reviews

9
Quick recovery from infection
After a careless dental procedure, I experienced swollen lymph nodes and an infection in the wounds. The dentist suggested strong antibiotics. Instead, I opted for this complex, knowing selenium could help. To my surprise, after two days, I returned to normal, astonishing my dentist. Now, I rely on this Superselenium complex for quick treatment of any infection or chills. Just be cautious with dosages and understand what you're taking.
Read More
7.5
Strengthens immune system
I've taken this for a short time but have already noticed a boost in my immune system. I experienced a viral infection and recovered almost unnoticed, with only minor symptoms that resolved in two days! I previously had longer-lasting colds. Doubling my daily iron dose may have contributed, but I feel energised and my symptoms of deficiency have disappeared.
Read More
7.5
Supports health benefits
6 people found this helpful
Selenium is an antioxidant that safeguards the health of cells and tissues, combating cell oxidation and numerous disorders, including impaired fertility. It's particularly beneficial for women regarding male fertility, weight loss, hair health, and bone strength. Selenium may help prevent heart disease, protect against Alzheimer's disease and mental decline, reduce cancer risk, and prevent miscarriage. Additionally, it might relieve asthma symptoms and boost the immune system to fight infection. I recommend supplementation due to these benefits, especially in light of our sedentary lifestyles and inadequate diets. I wish everyone success.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
  • All Researches
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.

In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.

Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.
Read More
9.5
Selenium nanoparticles combat bacterial infections
We explored how selenium nanoparticles (SeNPs) can tackle bacterial infections, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA). By modifying the surface chemistry of SeNPs using different surfactants, we could influence their effectiveness in fighting bacteria and modulating immune responses.

Our findings showed that selenium nanoparticles with anionic surfactants, specifically letinan (LET), had the greatest impact against MRSA. They generated high levels of reactive oxygen species (ROS) that damaged bacterial cell walls, demonstrating a powerful bactericidal action. In addition to killing bacteria, LET-SeNPs also effectively activated the body’s immune cells, enhancing the ability of macrophages to engulf and destroy the bacteria.

In tests with mice, treatment with LET-SeNPs not only cleared MRSA infection but also promoted faster wound healing by boosting the activity of important immune cells. This exciting research highlights the potential of engineered selenium nanoparticles to serve as effective dual-functional agents against stubborn bacterial infections.
Read More
9.5
We delved into how selenium nanoparticles (SeNPs) can raise our body's defenses against bacterial infections, specifically Mycobacterium bovis, which causes tuberculosis. The study focused on combining SeNPs with an antigen called AH (Ag85A-HspX) to see if this partnership could improve respiratory mucosal immunity and enhance protection against this serious illness.

In our exploration, we synthesized SeNPs and administered them intranasally in mice, alongside the AH antigen. The results were quite enlightening. SeNPs proved to be more effective than polyinosinic-polycytidylic acid (Poly IC) in stimulating dendritic cells, which play a crucial role in activating our immune response. This activation led to a significant increase in tissue-resident memory T cells and effector CD4 T cells in the lungs, strengthening the overall immune response to the infection.

Moreover, mice that received the combination of AH and SeNPs demonstrated impressive outcomes. There was a notable increase in specific antibody levels in the respiratory system, along with a boost in immune markers associated with fighting infections. Not only did these mice show enhanced mucosal immunity, but they also had lower infection loads and reduced inflammatory damage in their lungs after being challenged with M. bovis. Overall, this study highlights the potential of selenium nanoparticles as innovative adjuvants in vaccines, paving the way for future clinical investigations in both cattle and possibly humans.
Read More
9.5
Nano-based treatment for infections
We explored how selenium-tellurium doped copper oxide nanoparticles (SeTe-CuO NPs) can effectively tackle bacterial infections and improve wound healing. This innovative study focused on the nanoparticles’ dual photodynamic and photothermal properties, which become activated under near-infrared (NIR) light.

In our findings, these nanoparticles demonstrated a remarkable ability to eradicate up to 99% of bacteria and showed significant inhibition of biofilm formation. This is crucial, as biofilms can make infections harder to treat. The in vitro tests established that these NPs effectively combat bacterial infections, leading us to believe they have practical applications for improving wound recovery.

We also observed that, when implemented in vivo, the SeTe-CuO NPs significantly accelerated the closure of wounds. They helped clear bacteria quickly from wounds, offering a promising solution for those struggling with infections. Overall, the study highlights a powerful new tool in the fight against multidrug-resistant bacteria, demonstrating its potential in advancing therapeutic interventions in wound management.
Read More
9
Hybrid nanoparticles show antibacterial promise
We explored how combining selenium-tellurium nanoparticles with zinc oxide can help tackle bacterial infections, especially those stubborn biofilms. The goal was to create a hybrid nanoparticle that could leverage both photodynamic and photothermal properties to effectively disrupt bacterial growth.

In our synthesis of these SeTe-ZnO nanoparticles, we observed a significant impact on both Gram-positive and Gram-negative bacteria. Not only did these nanoparticles show efficacy in combating various bacterial strains, they also played a role in disrupting biofilm formation, which is often a major barrier to treatment success.

Furthermore, studies indicated that the SeTe-ZnO nanoparticles are biocompatible, which means they are safe to use in biological contexts, such as wound healing. Their impressive wound healing abilities suggest they could be a versatile option in both preventing and treating infections, demonstrating promising potential in the field of antimicrobial therapy.
Read More

User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Quick recovery from infection
After a careless dental procedure, I experienced swollen lymph nodes and an infection in the wounds. The dentist suggested strong antibiotics. Instead, I opted for this complex, knowing selenium could help. To my surprise, after two days, I returned to normal, astonishing my dentist. Now, I rely on this Superselenium complex for quick treatment of any infection or chills. Just be cautious with dosages and understand what you're taking.
Read More
7.5
Strengthens immune system
I've taken this for a short time but have already noticed a boost in my immune system. I experienced a viral infection and recovered almost unnoticed, with only minor symptoms that resolved in two days! I previously had longer-lasting colds. Doubling my daily iron dose may have contributed, but I feel energised and my symptoms of deficiency have disappeared.
Read More
7.5
Supports health benefits
6 people found this helpful
Selenium is an antioxidant that safeguards the health of cells and tissues, combating cell oxidation and numerous disorders, including impaired fertility. It's particularly beneficial for women regarding male fertility, weight loss, hair health, and bone strength. Selenium may help prevent heart disease, protect against Alzheimer's disease and mental decline, reduce cancer risk, and prevent miscarriage. Additionally, it might relieve asthma symptoms and boost the immune system to fight infection. I recommend supplementation due to these benefits, especially in light of our sedentary lifestyles and inadequate diets. I wish everyone success.
Read More
7.5
Boosts immunity effectively
1 people found this helpful
A wonderful antioxidant that's essential, particularly in old age. I advise everyone to use it, especially during these stressful times of infection, to enhance the body's immunity. I can't do without it, and neither can my family members.
Read More
7.5
Helps combat infection
Together with my relatives, we've started taking it to strengthen our immunity. I already take it to combat infection, as I've heard it aids in eliminating infections in the body.
Read More

Frequently Asked Questions

9
Quick recovery from infection
After a careless dental procedure, I experienced swollen lymph nodes and an infection in the wounds. The dentist suggested strong antibiotics. Instead, I opted for this complex, knowing selenium could help. To my surprise, after two days, I returned to normal, astonishing my dentist. Now, I rely on this Superselenium complex for quick treatment of any infection or chills. Just be cautious with dosages and understand what you're taking.
7.5
Strengthens immune system
I've taken this for a short time but have already noticed a boost in my immune system. I experienced a viral infection and recovered almost unnoticed, with only minor symptoms that resolved in two days! I previously had longer-lasting colds. Doubling my daily iron dose may have contributed, but I feel energised and my symptoms of deficiency have disappeared.
7.5
Helps combat infection
Together with my relatives, we've started taking it to strengthen our immunity. I already take it to combat infection, as I've heard it aids in eliminating infections in the body.
7.5
Supports health benefits
6 people found this helpful
Selenium is an antioxidant that safeguards the health of cells and tissues, combating cell oxidation and numerous disorders, including impaired fertility. It's particularly beneficial for women regarding male fertility, weight loss, hair health, and bone strength. Selenium may help prevent heart disease, protect against Alzheimer's disease and mental decline, reduce cancer risk, and prevent miscarriage. Additionally, it might relieve asthma symptoms and boost the immune system to fight infection. I recommend supplementation due to these benefits, especially in light of our sedentary lifestyles and inadequate diets. I wish everyone success.
6
Prevents infections
This remarkable complex contains three forms of selenium and vitamin E. It's essential since the human body cannot produce selenium. It's an important antioxidant that protects against ageing and can prevent the onset of both viral and bacterial infections while reducing inflammation. I take it with iodine to enhance absorption.
6
Improves infection resistance
I purchased this for both myself and my husband. Selenium with vitamin E is a potent combo that enhances the body's resistance to infections and viruses. It's an essential trace element for supporting the thyroid gland. Previously, we took a pharmacy product for prevention, but decided to switch to this after reading favourable reviews.
7
Selenium may protect against infection
We aimed to understand how exposure to selenium, a trace element, affects the risk of Streptococcus infection in children. Our study utilized data gathered from over 100,000 pregnancies across Japan, providing a comprehensive look at maternal health and child outcomes.

We specifically focused on measuring levels of toxic metals and trace elements in pregnant mothers and assessing the incidence of Streptococcus infections in their children around the age of three to four. Through our analysis, we found that higher levels of selenium were associated with a reduced risk of Streptococcus infections.

Interestingly, while both selenium and mercury appeared to have protective associations with infection rates, our examination did not find any significant interaction between these two elements. These findings suggest that maternal selenium exposure could play a beneficial role in safeguarding children from this common bacterial infection.
We explored the potential of selenium nanoparticles (SeNPs) as a treatment option for Pseudomonas aeruginosa, a notorious bacteria known for its antibiotic resistance and ability to form biofilms. The study examined how effectively these SeNPs can target bacterial infections, particularly focusing on their antibacterial and anti-biofilm properties.

SeNPs were made using ascorbic acid as a reducing agent and were characterized in detail. We noted that the SeNPs were around 15-18 nm in size and had distinct crystalline structures, confirmed through various analytical methods. The findings revealed that P. aeruginosa exhibited significant resistance to commonly used antibiotics, which makes the quest for alternative treatments even more critical.

Importantly, our results demonstrated that SeNPs could significantly inhibit biofilm formation in a dose-dependent manner. We found that the minimum inhibitory concentrations (MIC50 and MIC90) were 60 μg/mL and 80 μg/mL, respectively. Post-treatment analysis showed a considerable reduction in biofilm thickness and bacterial adherence, suggesting that SeNPs hold promise as a supplementary treatment option for infections caused by this resilient bacterium.

Overall, this study points to the potential of selenium nanoparticles in combating antibiotic-resistant Pseudomonas aeruginosa infections, opening pathways for further research in clinical applications.
We explored how modifying curcumin can enhance its efficacy as a photosensitizer in fighting bacterial infections, focusing particularly on Staphylococcus aureus. In our study, we compared synthetic curcumin with three modified versions, each incorporating selenium, chlorine, or iodine.

By exposing the bacteria to light after treating them with these curcumin variants, we aimed to observe their ability to produce reactive oxygen species that can kill bacteria. Interestingly, we found that the modifications, especially with selenium, significantly reduced bacterial viability, achieving roughly a 3-log reduction in counts.

Alike the synthetic version, the selenium-modified curcumin reached saturation in uptake at about 20 minutes. Overall, these insights indicate that modifying curcumin can indeed impact its photodynamic properties and may bolster its application in antimicrobial therapies.
We investigated how selenium-infused bandages can help prevent bacterial infections in wounds. By attaching organo-selenium compounds to cotton fabric, we created a bandage designed to kill harmful bacteria, including strains resistant to traditional antibiotics, like MRSA.

In our study, we used a mouse model to simulate wound infections. We placed the selenium-coated bandages on wounds and introduced bacteria directly into the area underneath the bandages. After five days, we examined the wounds and the bandages for signs of bacterial growth.

Remarkably, we observed that the bandages effectively protected the wounds, showing no bacterial presence after the five days of monitoring. This suggests that selenium remains effective even after washing, potentially offering a new approach to managing infections in medical settings.

References

  1. Iwata H, Ikeda A, Itoh M, Ketema RM, Tamura N, et al. Association between prenatal exposure to maternal metal and trace elements and Streptococcus infection: A prospective birth cohort in the Japan Environment and Children's Study. PLoS One. 2025;20:e0319356. doi:10.1371/journal.pone.0319356
  2. Wang Y, Khan SS, Ullah I, Rady A, Aldahmash B, et al. One pot synthesis of SeTe-ZnO nanoparticles for antibacterial and wound healing applications. RSC Adv. 2025;15:3439. doi:10.1039/d4ra06594h
  3. Perfileva AI, Zakharova OV, Graskova IA, Krutovsky KV. Effect of Selenium, Copper and Manganese Nanocomposites in Arabinogalactan Matrix on Potato Colonization by Phytopathogens and . Plants (Basel). 2024;13. doi:10.3390/plants13243496
  4. Dong J, Wang Z, Fei F, Jiang Y, Jiang Y, et al. Selenium Enhances the Growth of Bovine Endometrial Stromal Cells by PI3K/AKT/GSK-3β and Wnt/β-Catenin Pathways. Vet Sci. 2024;11. doi:10.3390/vetsci11120674
  5. Thamayandhi C, El-Tayeb MA, Syed SR, Sivaramakrishnan R, Gunasekar B. Antibacterial and anti-biofilm efficacy of selenium nanoparticles against Pseudomonas aeruginosa: Characterization and in vitro analysis. Microb Pathog. 2024;196:106998. doi:10.1016/j.micpath.2024.106998
  6. Tran P, Abidi N, Bergfeld N, Shashtri M, Reid TW. Selenium Bandages and Cotton Cloth That Kill Microorganisms in Wounds. Mil Med. 2024;189:179. doi:10.1093/milmed/usae069
  7. Wang Y, Feng L, Jiang WD, Wu P, Liu Y, et al. The effect of selenium on the intestinal health of juvenile grass carp based on the ERS-autophagy pathway. Fish Shellfish Immunol. 2024;153:109808. doi:10.1016/j.fsi.2024.109808
  8. Canbaz FA, Yurtçu M, Oltulu P, Taştekin G, Kocabaş R, et al. Investigation of the Effects of N-acetylcysteine and Selenium on Vesicoureteral Reflux Nephropathy: An Experimental Study. J Pediatr Surg. 2024;59:161616. doi:10.1016/j.jpedsurg.2024.06.024
  9. Gamal AA, Hussein MAM, Sayed HAE, El-Sayed EM, Youssef AM, et al. Hybrid nanoparticles combining nanoselenium-mediated Carica papaya extract and trimethyl chitosan for combating clinical multidrug-resistant bacteria. Int J Biol Macromol. 2024;277:134359. doi:10.1016/j.ijbiomac.2024.134359
  10. Joshi P, Soares JM, Martins GM, Zucolotto Cocca LH, De Boni L, et al. Enhancing the efficacy of antimicrobial photodynamic therapy through curcumin modifications. Photochem Photobiol. 2025;101:359. doi:10.1111/php.14000
  11. Gokhale KM, Patravale V, Pingale R, Pandey P, Vavilala SL. Se-functionalized ZIF-8 nanoparticles: synthesis, characterization and disruption of biofilms and quorum sensing in. Biomed Mater. 2024;19. doi:10.1088/1748-605X/ad6549
  12. Bian Y, Zhao K, Hu T, Tan C, Liang R, et al. A Se Nanoparticle/MgFe-LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction. Adv Sci (Weinh). 2024;11:e2403791. doi:10.1002/advs.202403791
  13. Bu Q, Jiang D, Yu Y, Deng Y, Chen T, et al. Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus Infection. Drug Resist Updat. 2024;76:101102. doi:10.1016/j.drup.2024.101102
  14. Ge X, Liang Z, Li K, Dong Y, Wang Y, et al. Selenium nanoparticles enhance mucosal immunity against Mycobacterium bovis infection. Int Immunopharmacol. 2024;137:112384. doi:10.1016/j.intimp.2024.112384
  15. Yang F, Shu R, Dai W, Li B, Liu C, et al. HSe-evolving bio-heterojunctions promote cutaneous regeneration in infected wounds by inhibiting excessive cellular senescence. Biomaterials. 2024;311:122659. doi:10.1016/j.biomaterials.2024.122659
  16. Ullah I, Khan SS, Ahmad W, Liu L, Rady A, et al. NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing. Commun Chem. 2024;7:131. doi:10.1038/s42004-024-01215-1
image